Objective: To explore the influence of different pit and fissure sealing materials combined with carisolv chemo-mechanical caries removal technique on the repair effect in children with dental caries. Methods: A total of 76 children with dental caries repair admitted to the hospital from May 2022 to May 2025 were selected. According to the method of generating random numbers by EXCEL random function, the children were divided into group A and group B, with 38 cases in each group. Both groups received carisolv chemo-mechanical caries removal technique. Group A was combined with resin sealing materials, while group B was combined with glass ionomer sealing materials. The excellent and good rate of repair effect, periodontal indexes [plaque index (PLI), sulcus bleeding index (SBI)], pain degree and incidence rates of complications were compared between the two groups of children. Results: At 6 months after treatment, group A demonstrated a higher excellent and good rate of repair effect compared to group B (P<0.05). However, no statistically significant differences were observed between the two groups in PLI score and SBI score (P>0.05). At 1, 3 and 6 months after treatment, VAS scores in both groups showed significant reductions compared to pre-treatment score, and group A had a higher VAS score at 1 month after treatment than group B (P<0.05). At 3 and 6 months after treatment, the differences in VAS scores between the two groups were not statistically significant (P>0.05). The incidence rates of complications in both groups showed no statistically significant differences (P>0.05). Conclusion: Carisolv chemo-mechanical caries removal technique combined with resin or glass ionomer pit and fissure sealing can both effectively improve the periodontal status and relieve pain in children with permanent teeth pit and fissure caries. The resin regimen has better long-term repair stability, and the glass ionomer regimen has milder short-term pain response and is more suitable for children with low pain tolerance.