Objective: To explore the clinical characteristics of patients with severe multiple bone and joint trauma and the therapeutic effect of damage control technology. Methods: A total of 82 patients with severe multiple bone and joint trauma who were treated in the hospital from April 2023 to April 2024 were selected and randomly divided into observation group (41 cases, damage control technology treatment) and control group (41 cases, conventional surgical treatment). The death and occurrence of complications in the two groups of patients during treatment were recorded. The clinical related indicators (body temperature recovery time, hospitalization time) were counted. The differences in coagulation function indicators were compared before treatment and after 1 week of treatment. Results: The body temperature recovery time and hospitalization time in observation group were significantly shorter than those in control group (P<0.05). After 1 week of treatment, the platelet count and fibrinogen in observation group were significantly higher than those in control group (P<0.05), and APTT was significantly shorter compared to control group (P<0.05). No significant difference was exhibited in the total incidence rate of complications between the two groups (P>0.05). Conclusion: Damage control technology can improve the coagulation function and accelerate the recovery process in patients with severe multiple bone and joint trauma, with high safety.