Objective: To explore the efficacy of N-acetylcysteine solution combined with beclomethasone propionate in the treatment of bronchopneumonia in children. Method: Sixty children with bronchopneumonia who visited our hospital from February 2023 to December 2024 were selected as the research subjects. The children were divided into the control group and the observation group by random number table method, with 30 cases in each group. The control group was treated with beclomethasone propionate. The observation group was treated with N-acetylcysteine solution combined with beclomethasone propionate. The therapeutic effects, disappearance time of main symptoms, inflammatory factors [Interleukin-6 (IL-6), C-reactive protein (CRP), Tumor necrosis factor-α (TNF-α)], immune function [immunoglobulin A (IgA), immunoglobulin G (IgG), complement C3] and the incidence of adverse reactions of the two groups were analyzed and compared. Result: The total effective rate of treatment in the observation group was significantly higher than that in the control group (P < 0.05). Compared with the control group, the disappearance time of cough and expectoration, fever, shortness of breath and moist rales in the lungs in the observation group was significantly shortened (P < 0.05). After treatment, the levels of IL-6, CRP and TNF-α in both groups were significantly lower than those before treatment, and the levels of IL-6, CRP and TNF-α in the observation group after treatment were significantly lower than those in the control group (P < 0.05). After treatment, the levels of IgA, IgG and C3 in both groups were significantly increased compared with those before treatment, and the levels of IgA, IgG and C3 in the observation group after treatment were significantly higher than those in the control group (P < 0.05). There was no significant difference in the adverse reaction rate between the two groups (P > 0.05). Conclusion: The combined therapy of N-acetylcysteine solution and beclomethasone propionate in the treatment of bronchopneumonia in children can improve the therapeutic effect, relieve clinical symptoms, inhibit the inflammatory response of the body, enhance the immune function, and has good safety.