Objective: To explore the efficacy of radiofrequency introduction of sodium alginate repair dressing combined with tranexamic acid injection in the treatment of chloasma. Methods: Eighty patients with chloasma admitted to the outpatient clinic from December 2023 to May 2025 were randomly divided into study group (n=40) and control group (n=40) by two-color ball method. The control group was treated with tranexamic acid injection, and the study group was combined with radiofrequency introduction of sodium alginate repair dressing on the basis of the control group. The clinical efficacy of the two groups of patients after 3 months of treatment was recorded. The melasma area and severity index (MASI) score was compared before treatment and after 3 months of treatment, and the physician’s global assessment (PGA) and patient satisfaction evaluation after treatment were compared between the two groups, and the adverse reactions during treatment were recorded. Results: After 3 months of treatment, the total effective rate in study group was higher than that in control group (P<0.05). The MASI score in the two groups was decreased, and the change in study group was more significant than that in control group (P<0.05). After 3 months of treatment, the PGA in study group was lower while the patient satisfaction was higher than that in control group (P<0.05). There were no significant differences in the incidence rates of adverse reactions between the two groups (P>0.05). Conclusion: Radiofrequency introduction of sodium alginate repair dressing combined with tranexamic acid injection in the treatment of chloasma can significantly enhance the clinical efficacy, remove the color spots, improve the facial status, and promote the repair of skin barrier function, with good safety.