Objective: To explore the application value of combined vaginal ultrasonography and abdominal ultrasonography in early diagnosis of ectopic pregnancy. Methods: A total of 86 suspected patients with ectopic pregnancy admitted to Xinzheng Public People"s Hospital from February 2022 to February 2024 were selected. Vaginal ultrasound and abdominal ultrasound were performed after admission. The gold standard was diagnostic curettage, and the gold standard results showed that 45 cases of ectopic pregnancy were confirmed and 41 cases of undiagnosed or other diseases were confirmed. Results: The diagnostic misdiagnosis rate of combined vaginal ultrasound and abdominal ultrasound was lower than that of single examination, and the diagnostic sensitivity, accuracy and specificity were higher than that of single examination (P < 0.05). Conclusion: In the early diagnosis of ectopic pregnancy, the combined application of vaginal ultrasound and abdominal ultrasound, as an effective combination of imaging examination, can further clarify the degree of lesions and development trend, and has high diagnostic efficiency, which is convenient to provide diagnostic basis for the subsequent clinical treatment of ectopic pregnancy, and significantly confirm its use value.