Objective: To explore the effects of empowering education combined with psychological nursing on mental disorders and pregnancy outcomes of pregnant women with threatened preterm birth.Methods: From August 2022 to August 2023, 80 pregnant women with threatened preterm birth were selected and divided into two groups according to the time of admission, 40 cases in each group, the control group was given routine psychological nursing, and the observation group was given empowerment education based on the control group.Stress perception Scale (CPSS), depression and anxiety self-rating scale and breast-feeding Self-efficacy Scale (BSES-SF) were used before and after the intervention. Preterm birth rate, gestational week, postpartum hemorrhage, puerperal infection, neonatal adverse outcomes, lactation initiation time and postpartum exclusive breast-feeding rate of 42d were recorded in both groups.Results: The CPSS scores of the observation group before delivery, one week after delivery and 42d after delivery were respectively(16.12±3.01), (13.42±3.79) and (11.91±3.58), while those of the control group were respectively(20.59±3.12), (18.23±2.04) and (17.38±4.62). The comparison were significant (P < 0.05).The scores of depression and anxiety before delivery, one week after delivery and 42d after delivery in the observation group were respectively (20.45±4.35), (22.38±5.52) and (13.34±4.65), ,while those in the control group were respectively(25.46±6.63), (27.63±5.24) and (20.52±6.63). The comparison were significant (P<0.05).In the observation group, the preterm birth rate was 12.50%, the gestational week of delivery was (38.93±1.02) weeks, and the postpartum massive hemorrhage rate was 0, while those in the control group was respectively 37.50%, (37.56±1.19) weeks, and 15.00%.The comparison were significant (P < 0.05). There were no statistical significance in adverse outcomes between the two groups (P > 0.05).The postpartum BSES score of the observation group was (58.41±7.47) points, the lactation initiation time was (37.63±6.58) h, the exclusive breastfeeding rate was 77.50%, and the control group were respectively (49.55±9.04) points, (50.11±11.34) h, 50.00%. The comparison were significant (P < 0.05).Conclusion: Active psychological care and strengthening empowerment education for preterm preterm mothers can effectively reduce their stress and improve their bad psychology, which not only helps to reduce the risk of preterm birth and postpartum hemorrhage, but also helps to enhance their sense of breastfeeding efficacy and increase the rate of breastfeeding.