Objective: To explore the application effect of multi-slice spiral CT combined with MRI in the clinical staging diagnosis of endometrial cancer. Methods: 160 patients with endometrial cancer admitted to the hospital from June 2023 to June 2025 were randomly selected as the study subjects and divided into a control group (n=80) and an observation group (n=80) according to different examinations. The control group underwent preoperative clinical staging evaluation using multi-slice spiral CT examination, while the observation group was diagnosed using multi-slice spiral CT combined with MRI. The diagnostic efficacy and imaging characteristics of the two groups of patients were subsequently compared. Results: Using pathological results as the gold standard, the overall accuracy of clinical staging diagnosis in the control group was 88.75%, which was much lower than the observation group"s 98.75% (P<0.05); The accuracy and sensitivity of Phase 1 diagnosis in the observation group were higher than those in the control group, and the specificity and accuracy of Phase II diagnosis in the observation group were higher than those in the control group (P<0.05); The imaging feature recognition of the observation group was more significant than that of the control group (P<0.05). Conclusion: The application of multi-slice spiral CT combined with MRI can improve the accuracy of clinical staging diagnosis of endometrial cancer, and provide guidance for the development of treatment plans, which is worthy of clinical promotion and application.