Objective: To explore and analyze the impact of nasal irrigation with a dual-salt nasal irrigation solution on the nasal mucociliary clearance function in patients with chronic sinusitis. Methods: A randomized controlled trial design was adopted. From May 2020 to May 2025, 121 patients with chronic sinusitis diagnosed and treated in our hospital were selected as the research subjects. According to the principle of random envelope drawing, these 121 patients were divided into an experimental group (61 cases) and a control group (60 cases). The control group received conventional drug therapy, while the experimental group received nasal irrigation with a dual-salt nasal irrigation solution in addition to the treatment given to the control group. Both groups were observed and treated for 4 weeks, and changes in nasal mucociliary clearance function were recorded. Results: After 4 weeks of treatment, the saccharin clearance time in both groups was significantly lower than that before treatment (P < 0.05). The saccharin clearance time in the experimental group after 4 weeks of treatment was also significantly lower than that in the control group (P < 0.05). The symptom scores for nasal congestion and runny nose in both groups after 4 weeks of treatment were lower than those before treatment (P < 0.05), and the scores in the experimental group after 4 weeks of treatment were significantly lower compared to the control group (P < 0.05). The serum levels of IL-1β and IL-6 in both groups after 4 weeks of treatment were lower than those before treatment (P < 0.05), and the levels in the experimental group after 4 weeks of treatment showed a statistically significant reduction compared to the control group (P < 0.05). The incidence rates of adverse reactions such as nasal dryness, nasal bleeding, nausea and vomiting, and dizziness during the 4-week treatment period were 0.00%, 1.64%, 1.64%, and 1.64% respectively in the experimental group, and 3.33%, 3.33%, 0.00%, and 1.67% respectively in the control group, with no significant difference between the two groups (P > 0.05). Conclusion: The application of nasal irrigation with a dual-salt nasal irrigation solution in patients with chronic sinusitis can improve nasal mucociliary clearance function, promote the alleviation of clinical symptoms such as nasal congestion and runny nose, and also inhibit the release of inflammatory factors, without increasing the incidence rate of adverse reactions.