Objective To explore and compare the therapeutic effects of concurrent treatment with obturator mid-urethral suspension and concurrent treatment with tension-free mid-urethral suspension on patients with uterine prolapse (POP) and stress urinary incontinence (SUI). Methods: 82 patients with POP combined with SUI who visited our hospital from January 2022 to December 2024 were selected as the research subjects. The patients were divided into the control group (n=41) and the observation group (n=41) by the random number table method. Both groups underwent pelvic floor reconstruction. On this basis, the control group was treated with tension-free mid-urethral suspension during the same period, while the observation group was treated with obturator mid-urethral suspension during the same period. The therapeutic effects, perioperative indicators, quality of life and incidence of complications of the two groups were analyzed and compared. Results The effective rate of treatment in the observation group was significantly higher than that in the control group (P<0.05). The operation time, intraoperative blood loss, catheterization time, postoperative VAS score and hospital stay of the observation group were significantly lower than those of the control group (P<0.05). Six months after the operation, the scores of the Pelvic Floor Disease Quality of Life Scale (PFIQ-7), the Pelvic Floor Dysfunction Scale (PEDI-20), and the Quality of Sexual Life Scale (POSQ-12) in both groups increased significantly compared with those before the operation (P<0.05), and the residual urine volume and the frequency of urinary incontinence measured by B-ultrasound decreased significantly compared with those before the operation (P<0.05). Moreover, the improvement amplitudes of the above indicators in the observation group were significantly greater than those in the control group (P<0.05). The incidence of dysuria in the observation group was significantly lower than that in the control group (P<0.05). Conclusion: Pelvic floor reconstruction combined with mid-urethral suspension via the obturator for concurrent treatment of uterine prolapse complicated with stress urinary incontinence can improve the clinical therapeutic effect. It has a short operation time, less trauma, quick recovery, and can effectively improve the pelvic floor function and urodynamics of patients, enhance the quality of life, reduce complications, and lower the recurrence rate.