Objective: To explore the clinical value of whole-brain CT perfusion (CTP) combined with head and neck CT angiography (CTA) in condition assessment of patients with transient ischemic attack (TIA). Methods: The clinical data of 60 patients with TIA admitted to the hospital from January 2023 to June 2025 were retrospectively analyzed. All patients received whole-brain CTP and head and neck CTA within 24 h after admission. According to whether they progressed to acute cerebral infarction (ACI) within 30 d after onset, patients were divided into the ACI group and the non-ACI group. Imaging parameters were compared between the two groups, and the predictive value of whole-brain CTP combined with head and neck CTA was analyzed using the ROC curve. Results: Among the 60 patients with TIA, 11 (18.33%) and 49 (81.67%) were assigned to the ACI group and the non-ACI group, respectively. There were statistically significant differences between the two groups in age, comorbidities (hypertension, diabetes, hyperlipidemia), the degree of vascular stenosis, CBV, CBF, MTT, and Tmax (P<0.05). Multivariate logistic regression analysis found that age, the degree of vascular stenosis, CBV, CBF, MTT, and Tmax were independent risk factors for TIA progressing to ACI (P<0.05). ROC curve analysis showed that the degree of vascular stenosis, CBV, CBF, MTT, and Tmax all demonstrated certain value in condition assessment of patients with TIA. The areas under the curve (AUCs) were 0.733 (95% CI: 0.614-0.786), 0.811 (95% CI: 0.716-0.857), 0.740 (95% CI: 0.715-0.834), 0.715 (95% CI: 0.648-0.765), and 0.716 (95% CI: 0.677-0.764), respectively (P<0.05). The AUC of combined prediction was the largest, which was 0.849 (95% CI: 0.770-0.893). Conclusion: Whole-brain CTP combined with head and neck CTA can help assess the condition of patients with TIA from both anatomical structure and functional perfusion perspectives. It is worthy of promotion and application in condition assessment of patients with TIA.