Objective: To explore the diagnostic value of non-invasive clinical indicators and Scheuer score for liver fibrosis in children. Methods: A retrospective analysis was conducted on 90 children patients with suspected liver fibrosis included from June 2023 to May 2025. They were grouped according to the Scheuer scoring system: Liver fibrosis groups: S0-S1: no obvious liver fibrosis group (35 cases), S2-S4: significant liver fibrosis group (55 cases); To analyze the diagnostic value of non-invasive clinical indicators and Scheuer scores for liver fibrosis in children. Results: Compared with the mild and moderate groups, the levels of ALT, AST, TBA, GGT, PT, APTT, FIB-4, and APRI in the severe group were all higher, while the levels of TP, ALB, and FBG were lower (P < 0.05). The results of multivariate Logistic regression analysis showed that ALT, AST, TBA, GGT, TP, ALB, PT, APTT, FBG, FIB-4, and APRI were independent risk factors affecting liver fibrosis in children (P < 0.05). Conclusion: Non-invasive clinical indicators combined with Scheuer score have certain diagnostic value for liver fibrosis in children and can provide an important basis for early clinical diagnosis and intervention.