Objective: To explore the application of tranexamic acid combined with hemabate on patients with postpartum hemorrhage due to uterine inertia and its influence on coagulation function. Methods: Pregnant women with uterine inertia symptom who were admitted to the hospital from January 2022 to January 2025 were included and divided into hemabate group (n=30) and combined group (n=30) by random number table method. The hemabate group was given intramuscular injection of 250 μg·time-1 of hemabate, while the combined group received hemabate (the same method as hemabate group) and intravenous drip of tranexamic acid. The maternal hemorrhage status (2 h postpartum hemorrhage volume, 24 h postpartum hemorrhage volume, hemostasis onset time), coagulation function indexes [prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-dimer], C-reactive protein (CRP) and adverse reactions were compared between the two groups. Results: The 2 h postpartum hemorrhage volume and 24 h postpartum hemorrhage volume in combined group were significantly less than those in hemabate group (P<0.05). The onset time of hemostasis in combined group was significantly shorter than that in hemabate group (P<0.05). At 24 h after delivery, PT, APTT and D-dimer in the two groups were significantly decreased (P<0.05), and the indexes in combined group were significantly lower than those in hemabate group (P<0.05). At 24 h after delivery, FIB in the two groups was increased significantly (P<0.05), and FIB in combined group was significantly higher than that in hemabate group (P<0.05). The level of CRP was significantly decreased at 24 h after delivery (P<0.05), and the level was significantly lower in combined group than that in hemabate group (P<0.05). There was no significant difference in the total incidence rate of adverse reactions between combined group (16.67%) and hemabate group (13.33%) (P>0.05). Conclusion: The combination of tranexamic acid and hemabate in the treatment of postpartum hemorrhage due to uterine inertia can effectively improve the hemorrhage status, enhance the coagulation function and reduce the inflammatory response. The treatment regimen has good safety and is worthy of clinical promotion and application.