Objective: To observe the effects of combined spinal-epidural anesthesia on hemodynamics of parturients undergoing cesarean section and neonates. Method: The clinical data of 88 parturients who underwent cesarean section in our hospital from December 2022 to November 2024 were collected. According to different anesthesia methods, the parturients were divided into the control group (receiving subarachnoid block anesthesia, 42 cases) and the observation group (receiving combined spinal-epidural anesthesia, 46 cases). The anesthesia-related indicators, hemodynamics [heart rate (HR) at the time of entering the room (T0), the onset of anesthesia (T1), the time of skin incision (T2), the end of the operation (T3), mean arterial pressure (MAP)], and newborns Apgar score, umbilical artery blood gas [umbilical artery blood pH value, partial pressure of oxygen (PaO2), partial pressure of carbon dioxide (PCO2)] and anesthesia-related adverse reactions of the two groups were statistically compared. Results: The onset time of anesthesia, the time for sensory block improvement, and the time for anesthesia recovery in the observation group were significantly shorter than those in the control group (P < 0.05). Compared with T0, HR and MAP in both groups decreased at T1 and rebounded from T2 to T3 (P < 0.05). HR and MAP in the observation group from T1 to T3 were significantly lower than those in the control group (P < 0.05). There were no significant differences in Apgar scores, umbilical cord blood pH, PaO2 and PCO2 levels, and the incidence of anesthesia-related adverse reactions between the two groups of newborns at 1 minute and 5 minutes after delivery (P > 0.05). Conclusion: Combined spinal-epidural anesthesia for cesarean section has a better stabilizing effect on the hemodynamics of parturients and can ensure the safety of mothers and infants.