基于术前实验室生物标志物的白内障术后视力恢复预测模型:一项队列研究
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上饶市中心医院

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上饶市科技计划医疗卫生指导性项目(编号:20241CZDX57);


Predicting the Clinical Efficacy of Anti-VEGF Monoclonal Antibody Therapy for Wet Age-Related Macular Degeneration Using Machine Learning Algorithms#
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    目的:探讨白内障患者术前实验室生物标志物与术后视力结局之间的关系。方法:回顾性纳入110例白内障超声乳化手术患者,收集人口统计学、术前BCVA及实验室检验数据。术后1个月评估BCVA,分组:优良结局(LogMAR BCVA ≤ 0.1)和欠佳结局(LogMAR BCVA > 0.1)。采用单变量和多变量逻辑回归分析筛选预测因子,构建模型并以AUC评估性能。结果:患者中80例优良,30例欠佳。单变量分析显示年龄、空腹血糖(FBG)和中性粒细胞与淋巴细胞比率(NLR)显著相关(P< 0.05)。多变量分析:年龄(OR:1.10,CI:1.03-1.18,p=0.007)、FBG(OR:2.25,CI:1.48-3.43,p<0.001)、NLR(OR:2.05,CI:1.39-3.02,p<0.001)为独立预测因子。模型AUC=0.84。结论:术前全身性因素,包括年龄、FBG和NLR,是术后视力恢复的关键预测指标。该模型基于常规低成本实验室数据,可助临床管理预期和识别高风险个体。

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    Objective: To investigate the relationship between preoperative laboratory biomarkers and postoperative visual outcomes in cataract patients. Methods: A retrospective study was conducted on 110 patients who underwent phacoemulsification cataract surgery. Demographic data, preoperative best-corrected visual acuity (BCVA), and laboratory test results were collected. BCVA was assessed one month postoperatively, and patients were grouped into two categories: good outcomes (LogMAR BCVA≤0.1) and poor outcomes (LogMAR BCVA>0.1) . Univariate and multivariate logistic regression analyses were used to identify predictive factors, construct models, and evaluate performance using AUC. Results: Among the patients, 80 had good outcomes and 30 had poor outcomes. Univariate analysis showed that age, fasting blood glucose (FBG), and neutrophil-to-lymphocyte ratio (NLR) were significantly associated (P<0.05). Multivariate analysis: Age (OR: 1.10, CI: 1.03–1.18,P=0.007), FBG (OR: 2.25, CI: 1.48–3.43, P<0.001), and NLR (OR: 2.05, CI: 1.39–3.02, P<0.001) were independent predictive factors. Model AUC = 0.84. Conclusion: Preoperative systemic factors, including age, FBG, and NLR, are key predictive indicators for postoperative visual recovery. This model, based on routine low-cost laboratory data, can assist in clinical management expectations and identify high-risk individuals.

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胡莹.基于术前实验室生物标志物的白内障术后视力恢复预测模型:一项队列研究[J].四川生理科学杂志,2025,47(12):

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  • 收稿日期:2025-09-01
  • 最后修改日期:2025-09-22
  • 录用日期:2025-09-30
  • 在线发布日期: 2026-01-04
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