Objective: To explore the risk factors of re-revascularization after PCI in patients with acute myocardial infarction. Methods: A retrospective analysis was conducted on the clinical data of 107 patients with acute myocardial infarction who underwent PCI treatment in our hospital from December 2022 to December 2024. They were divided into the re-revascularization group (28 cases) and the non-re-revascularization group (79 cases) based on whether re-revascularization was performed. Multivariate logistic regression was used to analyze the risk factors of re-revascularization after PCI in patients with acute myocardial infarction. Results: The incidence of re-revascularization after PCI in patients with acute myocardial infarction was 26.17%. The proportions of patients with smoking, hypertension, diabetes, secondary malignant arrhythmia and incomplete revascularization, as well as the levels of FBG and UA in the re-revascularization group were higher than those in the non-re-revascularization group (P < 0.05). Logistic regression analysis showed that secondary malignant arrhythmia, smoking, diabetes, hypertension, and incomplete revascularization were independent risk factors for re-revascularization after PCI in patients with acute myocardial infarction (P < 0.05). Conclusion: Factors such as secondary malignant arrhythmia, smoking, diabetes, hypertension and incomplete revascularization are closely related to the occurrence of re-revascularization after PCI in patients with acute myocardial infarction.