Objective: To explore the application effect of doxofylline and low-dose glucocorticoid in elderly patients with asthma.Methods: 206 elderly patients with asthma admitted to Henan Electric Power Hospital from January 2022 to December 2024 were randomly divided into two groups using computer randomization. The control group received low-dose corticosteroid treatment, while the study group received combined treatment (low-dose corticosteroid and doxofylline), with 103 patients in each group. The treatment effect was analyzed.Results: TThe lung function of the study group was higher than that of the control group (P < 0.05). The improvement time of symptoms in the study group was shorter than that in the control group (P < 0.05). The blood gas index of the study group was better than that of the control group (P < 0.05). The adverse reactions in the study group were lower than those in the control group, (P < 0.05).Conclusion: Low dose corticosteroids and doxofylline can significantly improve lung function, shorten symptom recovery time, and improve arterial blood gas levels in elderly asthma patients, and are worthy of promotion and use.