Objective: To investigate the effect of intermittent oxygen-driven aerosol inhalation combined with NIPPV on blood gas indicators and airway inflammation in patients with AECOPD so as to provide a basis for optimizing clinical treatment plans. Methods: Using a random number table, 60 patients with AECOPD admitted to Gongqingcheng People"s Hospital from June 2022 to June 2025 were divided into a control group (NIPPV, n=30) and an observation group (intermittent oxygen-driven aerosol inhalation combined with NIPPV, n=30). The blood gas indicators (PaO2, PaCO2), inflammatory factors (CRP, PCT), and quality of life (CAT score) were compared between the two groups of patients before and after treatment. Results: After treatment, the observation group showed an increase in PaO2, and decreases in PaCO2, CRP and PCT levels as well as CAT score compared to the control group (P<0.05). Conclusion: Applying intermittent oxygen-driven aerosol inhalation combined with NIPPV to treat AECOPD can improve patients" blood gas indicators more effectively, lower the levels of inflammatory factors such as CRP and PCT, alleviate symptoms, and improve the quality of life.