Objective: To explore the influence of nasal endoscopic low-temperature ablation of adenoids on the clinical outcomes of children with chronic sinusitis. Methods: The experimental group randomly selected 110 children with chronic sinusitis and adenoid hypertrophy who received? nasal endoscopic low-temperature ablation of adenoids in the hospital from January 2022 to December 2024, and the control group randomly included 110 children with chronic sinusitis and adenoid hypertrophy who received conservative treatment in the hospital from January 2022 to December 2024. The symptoms scores [Sino-Nasal Outcome Test-5 (SN-5), nasal endoscopy quantitative score (Lund-Kennedy)] and serum inflammatory factors [interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-5 (IL-5)] before and after treatment, clinical efficacy and occurrence of complications were compared between the two groups of patients. Results: After treatment, the SN-5 score, Lund-Kennedy score, IFN-γ, TNF-α and IL-5 in experimental group were significantly lower than those in control group (P<0.05). The total effective rate in experimental group was significantly higher than that in control group (P<0.05). There was no statistical difference in the total incidence rate of complications between the two groups (P>0.05) Conclusion: Nasal endoscopic low-temperature ablation of adenoids can significantly improve the symptoms of children with chronic sinusitis, effectively reduce the levels of inflammatory factors in nasal secretions, and enhance the clinical efficacy.