Objective: To explore the influence of goal-oriented intervention on postoperative complications and psychological resilience of patients undergoing aortic dissection surgery. Methods: From January 2022 to January 2024, 100 patients who underwent endovascular isolation of aortic dissection were selected and randomly divided into two groups, with 50 cases in each group. The control group received routine care, while the observation group adopted intervention measures guided by the goal-oriented theory. Compare the complications and psychological resilience of patients. Results: The psychological resilience and quality of life of the observation group after intervention were higher than those of the control group (P < 0.05). The proportion of complications in the observation group was lower than that in the control group (P < 0.05). Conclusion: The intervention strategies under the goal-oriented theory are helpful to reduce the complications of patients undergoing aortic dissection isolation and enhance their psychological resilience, providing a scientific basis and new ideas for clinical nursing.