Objective: To explore the application effect and anesthesia safety of ramizolam tosylate in patients under general anesthesia.Methods: From August 2023 to June 2025, 80 patients with general anesthesia admitted to the First Affiliated Hospital of Henan University of Science and Technology were selected to participate in the study, and they were randomly divided into two groups by computer. The study group was given rimazolam and the control group was given propofol, with 40 patients in each group, and the anesthesia effect was analyzed.Results: The adverse reactions in the study group were lower than those in the control group, P < 0.05. HR and MAP in the study group were lower than those in the control group, P < 0.05. Comparison of Sao 2 between the two groups, P > 0.05. BIS index of study group was lower than that of control group, P < 0.05.Conclusion: Remazolam is safe and effective in patients under general anesthesia, which can significantly reduce the risk of adverse reactions and stabilize the vital signs of patients, and is worth popularizing.