Objective To observe the effect of PDCA quality control cycle management combined with multi-department collaborative intervention on the quality of the first page filling of inpatient medical records. Methods: The medical record data of 110 inpatients who received conventional management and multi-department collaborative intervention in our hospital from January 2023 to December 2023 were retrospectively collected and included in the control group. The medical record data of 110 inpatients who received PDCA quality control cycle management combined with multi-department collaborative intervention from January 2024 to December 2024 were collected and included in the observation group. The diagnostic quality control indicators, responsibility for diagnostic errors and management quality (DRG score) of the two groups were statistically compared. Results: The number of cases with complete homepage data, the number of cases with correct selection of the main diagnosis, and the number of cases with correct selection of the main diagnostic code in the observation group were significantly higher than those in the control group (P < 0.05). The number of errors made by clinicians, by coders, and by both in the observation group was significantly lower than that in the control group (P < 0.05). The scores of the validity of the main diagnostic code, the rationality of the main diagnostic selection, and the standardization of the combined code in the observation group were all significantly higher than those in the control group (P < 0.05). Conclusion: The PDCA quality control cycle management combined with multi-department collaborative intervention can improve the quality of the first page filling of medical records, reduce the occurrence of systematic errors related to medical record filling, and enhance the quality of medical record management.