Objective: To Analyze the impact of laparoscopic and open myomectomy on the levels of CRP, TNF - α, and prognosis of patients with uterine fibroids. Methods: 80 patients with uterine fibroids in our hospital were selected from January 2022 to December 2024 and randomly divided into an observation group and a control group, with 40 patients in each group. Compare two groups of perioperative indicators (bleeding volume, operation time, anal exhaust time, hospital stay), ovarian function, stress indicators, inflammatory factors, complications, and quality of life comprehensive evaluation questionnaire (GQOLI74). Results:The observation group showed better bleeding volume, operation time, anal exhaust time, and length of hospital stay than the control group (P<0.05); After surgery, the levels of FSH and LH in the observation group were lower than those in the control group, and the level of E2 was higher than that in the control group (P<0.05); After surgery, the levels of SP, Cor, and NE in the observation group were lower than those in the control group (P<0.05); After surgery, the levels of CRP, IL-6, and TNF - α in the observation group were lower than those in the control group (P<0.05); The incidence of complications in the observation group was lower in one patient compared to the control group of eight patients (P<0.05); The psychological function, material life, and social function scores of the observation group were higher than those of the control group (P<0.05). Conclusion: Laparoscopic myomectomy can alleviate the impact on ovarian function in uterine fibroids, resulting in less stress response and inflammatory symptoms, reducing complications, and improving quality of life.