Objective To investigate the effects of red and blue light irradiation combined with vitamin A capsules and minocycline on acne vulgaris. Method: According to the random number table method, the patients with acne vulgaris admitted to our hospital from January 2022 to January 2024 were divided into a control group and a study group, with a total of 92 cases. The control group was treated with vitamin A ester capsules and minocycline; The research group combined red and blue light irradiation therapy. Compare the clinical efficacy, inflammatory lesion scores, inflammatory factors [interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor - α (TNF - α)], and quality of life [Health Survey Questionnaire (36-tem Short Form, SF-36)] between two groups, and calculate the incidence of adverse reactions between the two groups. Results: The total effective rate of the study group was higher than that of the control group (P<0.05). After treatment, the scores of papules, pimples, pustules, and nodules in the study group were lower than those in the control group (P<0.05). After treatment, the average levels of IL-1, IL-6, and TNF - α in the research group were lower than those in the control group (P<0.05). After treatment, the SF-36 scores of the research group were higher than those of the control group (P<0.05). There was no statistically significant difference in adverse reactions between groups (P>0.05). Conclusion: The combination of red and blue light irradiation with vitamin A capsules and minocycline is effective in treating acne vulgaris, improving skin lesion symptoms, reducing serum inflammatory factor levels, promoting prognosis and quality of life, and has high safety.