Objective:To explore the clinical effect of minimally invasive reduction, cerclage combined with extended anti-rotational intramedullary nail (PFNA) in the treatment of femoral subtrochantericfractures.Methods:One hundred and eighteen patients with subtrochanteric fractures to be treated in our hospital were selected as research objects. According to the order of patients" admission, they were divided into observation group and control group, with 59 patients in each group. Cerclage combined with PFNA treatment; comparison of surgical time, bleeding volume, hospital stay, fracture healing time, reduction effect, hip varus angle, hip function, and surgical complication rate between the two groups.Results:There was no significant difference in the operation time and fracture healing time between the observation group and the control group (P>0.05). The blood loss and hospital stay of the observation group were lower than those of the control group (P<0.05). The reduction difference in sagittal and coronal planes and hip varus angle of the observation group were lower than those of the control group (P<0.05); the anatomical reduction rate of the observation group was higher than that of the control group (P<0.05); The hip joint range of motion of patients in the observation group and the control group was measured at 3 months and 6 months after the operation respectively. The range of motion of hip flexion function, adduction and internal rotation function of patients in the observation group at 3 months after the operation was greater than that of patients in the control group, and the difference was statistically significant (P<0.05).Patients in the group were evaluated for function at 6 months after operation. In general, there was no significant difference in Harris function distribution between the two groups (P>0.05). The surgical complication rate in the observation group was 6.78% lower than that in the control group, 20.34%. The difference was statistically significant (P<0.05).Conclusion: Minimally invasive reduction, cerclage combined with PFNA for the treatment of subtrochanteric fractures of the femur have a better reduction effect than traditional open reduction PFNA treatment, less surgical trauma, and lower postoperative complications.