Objective: To investigate the effect of sperm morphology on the clinical outcomes of In Vitro Fertilization Embryo Transfer (IVF-ET). Method: The Reproductive Medicine and Genetics Center of Luohe Central Hospital analyzed the semen of 700 fresh egg retrieval cycles treated with assisted reproductive technology based on the staining method and evaluation criteria of the WHO "Laboratory Manual for Human Semen Examination and Processing (5th edition)". The research plan is divided into two groups: conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Each group is further divided into three subgroups: Group A: severely deformed sperm with a normal morphology rate of ≤ 1%; Group B: Moderately deformed sperm, 1%0.05) in the general information of patients.There was no statistically significant difference in embryo cleavage rate, high-quality embryo rate, blastocyst formation rate, and clinical pregnancy rate between IVF and ICSI (P>0.05). However, in the IVF group, the total fertilization rate and abnormal fertilization rate (≥ 3PN) increased significantly with the increase of normal sperm morphology rate (P<0.05). Conclusion: Sperm morphology rate in conventional assisted reproductive technology treatment, without considering other male factors, although has no significant effect on the quality of embryo development, normal fertilization rate, or clinical pregnancy outcome, can cause a decrease in the overall fertilization rate of IVF assisted reproductive population.