Objective To study on the clinical efficacy and long-term follow-up results of stent combined with micro coil intervention in the treatment of intracranial aneurysms. Methods 83 patients with intracranial aneurysm who received treatment in our hospital from January 2022 to January 2024 were selected as the study objects. Patients were divided into control group (n=41) and study group (n=42) by random number table method. Compare the success rate of embolization, consciousness impairment [Glasgow Coma Scale (GCS)], inflammatory cytokines [interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor - α (TNF - α)], incidence of adverse events, tumor recurrence rate, and mortality rate between two groups. Results The success rate of embolization in the research group was significantly higher than that in the control group (P<0.05). After treatment, the GCS score of both groups was significantly higher than that before treatment (P<0.05), and the GCS score of the study group was significantly higher than that of the control group (P<0.05). After treatment, the levels of TNF-α, IL-1 and IL-6 in both groups were significantly lower than before treatment, and the levels of TNF-α, IL-1 and IL-6 in the study group were significantly lower than those in the control group (P<0.05). The incidence of adverse events,the recurrence rate and mortality rate of the tumor in the study group was significantly lower than that in the control group (P<0.05). Conclusion Patients with intracranial aneurysms can be treated with stent combined with micro coil intervention, which can improve clinical efficacy, alleviate consciousness disorders, reduce inflammatory cytokines, decrease postoperative adverse events and the risk of recurrence and death, and improve patient prognosis.