宫腔镜手术改善EPs患者子宫内膜容受性的临床研究
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河南省焦作市博爱县妇幼保健院

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Clinical Study on Hysteroscopic Surgery Improving Endometrial Receptivity in Patients with Endometrial Polyps
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    摘要:

    目的 探讨宫腔镜手术对子宫内膜息肉(endometrial polyps,EPs)患者子宫内膜容受性的改善作用。方法 选取2023年1月至2024年12月期间于本院进行治疗的120例EPs患者作为研究对象。采用随机数字表法将患者分为对照组和观察组,每组各60例。对照组采用传统刮宫术治疗;观察组采用宫腔镜手术治疗。分析对比两组的手术相关指标、子宫内膜容受性[子宫内膜厚度、整合素β3、白血病抑制因子的表达水平]以及并发症发生率。结果 观察组的术中操作时间、手术出血情况、术后阴道流血时间、住院时间均显著少于对照组(P<0.05)。术后3个月,两组的子宫内膜厚度、整合素β3、白血病抑制因子水平均比术前显著升高,且观察组的子宫内膜厚度、整合素β3、白血病抑制因子水平均显著高于对照组(P<0.05)。观察组的并发症发生率显著低于对照组(P<0.05)。结论 宫腔镜手术治疗EPs,相较于传统刮宫术,不仅能有效缩短手术时间,减少术中出血及术后恢复时间,还能显著改善患者子宫内膜容受性,降低并发症发生率。

    Abstract:

    Objective Exploring the Improving Effects of Hysteroscopic Surgery on Endometrial Receptivity in Patients with Endometrial Polyps (EPs). Methods 120 patients with EPs who were treated in our hospital from January 2023 to December 2024 were selected as the study objects. Patients were divided into control group and observation group by random number table method, with 60 cases in each group. The control group was treated with traditional curettage. The observation group was treated with hysteroscopic surgery. Surgery-related indexes, endometrial receptivity [endometrial thickness, integrin β3, leukemia inhibitor expression levels] and complication rate of the two groups were analyzed and compared. Results The operation time, operation bleeding, postoperative vaginal bleeding time and hospital stay in the observation group were significantly less than those in the control group (P<0.05). Three months after surgery, the endometrial thickness, integrin β3 and leukemia inhibitor levels in both groups were significantly higher than those before surgery, and the endometrial thickness, integrin β3 and leukemia inhibitor levels in the observation group were significantly higher than those in the control group (P<0.05). The complication rate of the observation group was significantly lower than that of the control group (P<0.05). Conclusion Compared with traditional curettage, hysteroscopic surgery for EPs can not only effectively shorten the operation time, reduce intraoperative bleeding and postoperative recovery time, but also significantly improve the endometrial tolerance of patients and reduce the incidence of complications.

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  • 收稿日期:2025-04-24
  • 最后修改日期:2025-06-10
  • 录用日期:2025-06-30
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