补肾化痰活血方治疗肾虚血瘀型复发性流产患者40例的临床疗效观察
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南阳市第一人民医院

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Observation on clinical effect of Bushen Huatan Huoxue prescription in treating 40 cases of recurrent abortion with kidney deficiency and blood stasis type
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    摘要:

    目的? 探讨补肾化痰活血方治疗肾虚血瘀型复发性流产(recurrentspontaneousabortion,RSA)患者的疗效。方法 选取2023年5月-2024年8月期间本院产科收治的肾虚血瘀型复发性流产患者40例作为研究对象。采用随机数字表法将患者分为对照组和观察组,每组各20例。对照组给予常规的保胎治疗。观察组在对照组基础上配合补肾化痰活血方治疗。分析对比两组的临床疗效、免疫功能[白细胞介素(interleukin,IL)-4、IL-1、IL-17水平]、中医证候评分、炎性因子[D-二聚体水平、TNF-α水平、IL-10水平]、妊娠结局以及疗效。结果 观察组的治疗总有效率显著高于对照组(P<0.05)。观察组的活产率显著高于对照组(P<0.05)。治疗后,两组的IL-1、IL-17水平均较治疗前显著升高,IL-4水平均比治疗前显著降低,且观察组治疗后的IL-1、IL-4、IL-17水平的变化幅度均显著大于对照组(P<0.05)。治疗后,两组的各项中医证候评分均较治疗显著降低,且观察组的各项中医证候评分均显著低于对照组(P<0.05)。治疗后,两组的D-二聚体和TNF-α水平均比治疗前显著下降,IL-10水平比治疗前显著上升;且观察组的D-二聚体、IL-10、TNF-α水平的变化幅度均显著大于对照组(P<0.05)。结论 选用补肾化痰活血方治疗肾虚血瘀型RSA患者,能够提高患者的临床疗效,改善患者的免疫功能,降低炎性因子水平和中医证候评分,改善妊娠结局。

    Abstract:

    objective to investigate the kidney and phlegm huoxue fang treatment of kidney and blood stasis in patients with recurrent miscarriage (recurrentspontaneousabortion, RSA) curative effect. Methods From May 2023 to August 2024, 40 patients with recurrent abortion with kidney deficiency and blood stasis were selected as the study objects. The patients were divided into control group and observation group by random number table method, with 20 cases in each group. The control group was given routine fetal preservation treatment. Observation group was treated with bushen Huatan Huoxue prescription on the basis of control group. Clinical efficacy, immune function [interleukin (IL)-4, IL-1, IL-17 levels], TCM syndrome score, inflammatory factors (D-dimer level, TNF-α level, IL-10 level), pregnancy outcome and efficacy of the two groups were analyzed and compared. Results The total effective rate of observation group was significantly higher than that of control group (P<0.05). The live birth rate of observation group was significantly higher than that of control group (P<0.05). After treatment, the levels of IL-1 and IL-17 in both groups were significantly higher than before treatment, and the levels of IL-4 were significantly lower than before treatment, and the changes in the levels of IL-1, IL-4 and IL-17 in the observation group after treatment were significantly greater than those in the control group (P<0.05). After treatment, the scores of TCM syndroms in both groups were significantly reduced, and the scores of TCM syndroms in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the levels of D-dimer and TNF-α in both groups were significantly decreased, and the levels of IL-10 were significantly increased. The levels of D-dimer, IL-10 and TNF-α in observation group were significantly higher than those in control group (P<0.05). Conclusion Bushen Huatan Huoxue formula can improve the clinical efficacy, immune function, inflammatory factors and TCM syndrome score of patients with kidney deficiency and blood stasis type RSA, and improve the outcome of pregnancy.

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苏纪春.补肾化痰活血方治疗肾虚血瘀型复发性流产患者40例的临床疗效观察[J].四川生理科学杂志,2026,48(5):

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  • 收稿日期:2025-04-17
  • 最后修改日期:2025-06-06
  • 录用日期:2025-06-13
  • 在线发布日期: 2026-05-20
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