Objective To investigate the correlation between liver function and coagulation function in patients with decompensated cirrhosis. Methods 153 patients with decompensated cirrhosis admitted to our hospital from January 2022 to December 2024 were selected as the study subjects. According to the different Child-Pugh grades, the patients were divided into B group (91 cases) and C group (62 cases). The liver function indexes (TBIL, DBIL, ALT, AST, ALB) and coagulation function indexes (PT, APTT, TT, INR) of the two groups were detected and compared. The correlation between liver function and coagulation function was studied by Pearson correlation analysis. Results The levels of TBIL, DBIL, ALT and AST in grade C group were significantly higher than those in grade B group (P < 0.05), while the level of ALB was significantly lower than that in grade B group (P < 0.05). PT, APTT and TT in grade C group were significantly longer than those in grade B group, and INR in grade C group was significantly higher than that in grade B group (P < 0.05). Correlation analysis showed that TBIL and DBIL were significantly positively correlated with coagulation indexes (r=0.583~0.702, P < 0.05), while ALT and AST were moderately positively correlated with coagulation indexes (r=0.521~0.647, P < 0.05). There was a significant negative correlation between ALB and coagulation index (r=-0.680~-0.726, P < 0.05). Conclusion There is a significant correlation between liver function and coagulation function in patients with decompensated cirrhosis. Compared with grade B, patients with grade C have more serious hepatocyte necrosis, cholestasis and coagulation factor synthesis disorders, and the abnormal degree of coagulation index is correlated with Child-Pugh grade.