Abstract:Objective: To investigate the relationship of serum brain natriuretic peptide (BNP), D-dimer (D-D) and cardiac function indicators with disease severity in patients with chronic heart failure and the value on predicting long-term death outcome. Methods: Referencing to the New York Heart Association (NYHA) cardiac function grading, 60 patients with chronic heart failure in the hospital from February 2021 to March 2024 were grouped, 20 cases with cardiac function grade II were set as mild group, and 27 cases with cardiac function grade III were enrolled as moderate group, and 13 cases with cardiac function grade IV were included in severe group. 60 patients with chronic heart failure were classified into occurrence group (n=17) and non-occurrence group (n=43) according to whether they died within 1 year. The levels of serum BNP, D-D and lactate dehydrogenase (LDH) in each group were compared. The predictive value of serum BNP, D-D and LDH levels on long-term death in patients with chronic heart failure was discussed by receiver operating characteristic (ROC) curve. Results: Compared with mild group, the levels of serum BNP, D-D and LDH in moderate and severe groups were higher, and the levels were higher in severe group compared to moderate group (P<0.05). Serum BNP, D-D and LDH levels were higher in occurrence group in comparison with non-occurrence group (P<0.05). BNP, D-D and LDH had high efficiency on predicting death in patients with chronic heart failure (P<0.001), and the areas under the curves (AUCs) were 0.777, 0.858 and 0.839, and the sensitivities were 88.27%, 70.59% and 60.47%, and the specificities were 82.35%, 97.67% and 76.74% respectively. Conclusion: The levels of BNP, D-D and LDH are positively correlated with the severity of chronic heart failure, and the three indicators can predict the long-term death outcome of patients. The higher the levels of BNP, D-D and LDH are, the higher the risk of long-term death is.