Objective:Exploring the therapeutic effect of hyperbaric oxygen combined with nerve growth factor on patients with acute carbon monoxide poisoning and its impact on plasma levels of nitric oxide and endothelin.Methods:From July 2023 to July 2024, 100 patients with acute carbon monoxide poisoning in our hospital were selected and randomly divided into a control group and a study group, with 50 patients in each group, using a random number table method. The control group received treatment with nerve growth factor, while the study group received treatment with hyperbaric oxygen combined with nerve growth factor. The serum enzyme indicators [creatine kinase (CK), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST)], plasma [endothelin-1 (ET-1), nitric oxide (NO)], MMSE score, HDS score, ADL score], incidence of complications between the two groups, and comparison of clinical effects between the two groups were compared and analyzed.Results:After treatment, the levels of CK, LDH, ALT, and AST in the study group were lower than those in the control group (P<0.05); The content of ET-1 in the research group was lower than that in the control group, and the content of NO was higher than that in the control group (P<0.05); The MMSE score, HDS score, and ADL score of the research group were higher than those of the control group (P<0.05); The total incidence of complications in the study group was lower than that in the control group (P<0.05); The total effective rate of the treatment in the research group was higher than that in the control group (P<0.05).Conclusion:The use of nerve growth factor combined with hyperbaric oxygen therapy has significant therapeutic effects in patients with acute carbon monoxide poisoning, improving plasma levels of nitric oxide and endothelin, promoting disease improvement, and has good clinical value.