Objective: To establish the risk factors and prediction model of cardiovascular death in maintenance hemodialysis patients，so as to provide guidance for early clinical intervention. Methods: Ninety-nine patients with routine maintenance hemodialysis admitted to Anyuan County People"s Hospital from January 2022 to December 2024 were selected. General data of all patients were collected. All patients underwent routine blood examination and routine serological index examination, and all patients were followed up for 3 months. Patients were divided into survival group (n=62), death from cardiovascular causes group (n=21) and death due to death group (n=16). General data and serological indicators of the three groups of patients were compared, and multi-factor logistics regression analysis was used to analyze the independent factors affecting the risk of death from cardiovascular causes of patients. Based on the analysis data of independent factors, a prediction model for the risk of death from cardiovascular causes of patients with maintenance hemodialysis was established. Results: Compared with the survival and non-death groups，the cardiovascular death group had significantly higher age，duration of hemodialysis，and levels of serum potassium，parathyroid hormone，and aspartate aminotransferase (P < 0.05) and significantly lower levels of serum calcium，phosphorus，hemoglobin，albumin，and total bilirubin (P < 0.05). Multivariate logistic regression analysis showed that age，hemodialysis time，serum calcium concentration，serum potassium concentration，serum phosphorus concentration，hemoglobin，albumin，parathyroid hormone and total bilirubin were all related factors affecting the occurrence of cardiovascular death in maintenance hemodialysis patients (P < 0.05). The results of ROC curve showed that the area under the curve of the constructed model was 0.941 (95%CI: 0.917-0.966)，the sensitivity was 85.6%，and the specificity was 90.1%，indicating that the risk prediction model had a good prediction effect. Conclusion: Multivariate logistic regression analysis showed that age，hemodialysis time，serum calcium concentration，hemoglobin，albumin，parathyroid hormone and total bilirubin levels were all related factors for cardiovascular death risk in maintenance hemodialysis patients，and the prediction model constructed by related factors had a good predictive effect.