Abstract:Objective: To analyze the association between creatine kinase (CK), red blood cell count (RBC), white blood cell count (WBC) and total protein in cerebrospinal fluid and risk of cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH), and to explore the value as potential biomarkers on predicting CVS. Methods: Totally 60 patients with SAH in the hospital from January 2022 to December 2024 were divided into CVS group and non-CVS group according to whether CVS occurred. The levels of CK, RBC, WBC and total protein in cerebrospinal fluid were compared, and the correlation between these indicators and risk of CVS after SAH was analyzed. Results: The levels of CK, RBC, WBC and total protein in cerebrospinal fluid of patients in CVS group were higher than those in non-CVS group (P<0.05). CK, RBC, WBC and total protein in cerebrospinal fluid in CVS group were positively correlated with the mean blood flow velocity of middle cerebral artery (r=0.413, 0.396, 0.374, 0.398, P<0.05). CK, RBC, WBC and total protein in cerebrospinal fluid had good efficiency on predicting CVS in SAH patients, and the areas under the curves were all >0.7. CK had the highest efficiency on predicting CVS in SAH patients. When the Youden index was the largest, the corresponding critical value, area under the curve, sensitivity and specificity were 129.99 U/L, 0.888, 88.51% and 79.41%. Conclusion: The changes of CK, RBC, WBC and total protein in cerebrospinal fluid are closely related to the risk of CVS after SAH, and they can be used as potential biomarkers to predict the occurrence of CVS after SAH, and provide new ideas and methods for clinical diagnosis and treatment.