脑脊液中CK、RBC、WBC及蛋白总量与蛛网膜下腔出血后脑血管痉挛风险的关系
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上饶市人民医院

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Relationship between CK, RBC, WBC and total protein in cerebrospinal fluid and risk of cerebral vasospasm after subarachnoid hemorrhage
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    摘要:

    目的:分析脑脊液中肌酸激酶(CK)、红细胞计数(RBC)、白细胞计数(WBC)及蛋白总量与蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)风险之间的关联,探讨其作为预测CVS发生的潜在生物标志物价值。方法:将本院2022年1月至2024年12月收治的60例SAH患者,按照是否发生CVS分为CVS组和无CVS组,比较两组患者脑脊液中CK、RBC、WBC及蛋白总量的水平,分析这些指标与SAH后CVS风险的相关性。结果:CVS组患者脑脊液中CK、RBC、WBC及蛋白总量水平均高于无CVS组(P<0.05);CVS组患者脑脊液CK、RBC、WBC及蛋白总量水平与大脑中动脉平均血流速度呈正相关(r=0.413、0.396、0.374、0.398,P<0.05);脑脊液中的CK、RBC、WBC及蛋白总量预测SAH患者发生CVS具有良好效能,曲线下面积均>0.7,CK预测SAH患者发生CVS效能最高,约登指数最大时,对应临界值为129.99 U/L,曲线下面积为0.888,敏感度为88.51%、特异性为79.41%。结论:脑脊液中CK、RBC、WBC及蛋白总量的水平变化与SAH后CVS风险密切相关,可作为预测SAH后CVS发生的潜在生物标志物,为临床诊断和治疗提供新的思路和方法。

    Abstract:

    Objective: To analyze the association between creatine kinase (CK), red blood cell count (RBC), white blood cell count (WBC) and total protein in cerebrospinal fluid and risk of cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH), and to explore the value as potential biomarkers on predicting CVS. Methods: Totally 60 patients with SAH in the hospital from January 2022 to December 2024 were divided into CVS group and non-CVS group according to whether CVS occurred. The levels of CK, RBC, WBC and total protein in cerebrospinal fluid were compared, and the correlation between these indicators and risk of CVS after SAH was analyzed. Results: The levels of CK, RBC, WBC and total protein in cerebrospinal fluid of patients in CVS group were higher than those in non-CVS group (P<0.05). CK, RBC, WBC and total protein in cerebrospinal fluid in CVS group were positively correlated with the mean blood flow velocity of middle cerebral artery (r=0.413, 0.396, 0.374, 0.398, P<0.05). CK, RBC, WBC and total protein in cerebrospinal fluid had good efficiency on predicting CVS in SAH patients, and the areas under the curves were all >0.7. CK had the highest efficiency on predicting CVS in SAH patients. When the Youden index was the largest, the corresponding critical value, area under the curve, sensitivity and specificity were 129.99 U/L, 0.888, 88.51% and 79.41%. Conclusion: The changes of CK, RBC, WBC and total protein in cerebrospinal fluid are closely related to the risk of CVS after SAH, and they can be used as potential biomarkers to predict the occurrence of CVS after SAH, and provide new ideas and methods for clinical diagnosis and treatment.

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黄丹坪.脑脊液中CK、RBC、WBC及蛋白总量与蛛网膜下腔出血后脑血管痉挛风险的关系[J].四川生理科学杂志,2025,47(6):

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  • 收稿日期:2025-04-14
  • 最后修改日期:2025-05-06
  • 录用日期:2025-05-09
  • 在线发布日期: 2025-06-22
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