Objective: To analyze the risk factors of recurrence in patients with hypertriglyceridemic acute pancreatitis. Methods: The clinical data of 64 patients with hypertriglyceridemic acute pancreatitis in the hospital from March 2023 to January 2024 were retrospectively analyzed. The enrolled patients were followed up for 1 year and divided into recurrence group (n=25) and non-recurrence group (n=39) according to whether recurrence occurred. Multivariate Logistic regression model was used to analyze the influencing factors of recurrence in patients with hypertriglyceridemic acute pancreatitis. Results: The proportions of hyperlipidemia, gout history, diabetes mellitus and body mass index≥24 kg/m2 and levels of triglyceride (TG), total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) before discharge in recurrence group were higher than those in non-recurrence group while the level of high density lipoprotein cholesterol (HDL-C) before discharge was lower than that in non-recurrence group (P<0.05). Multivariate Logistic regression model showed that diabetes mellitus, body mass index≥24 kg/m2, high levels of TG, TC and LDL-C and low level of HDL-C before discharge were independent risk factors of recurrence in patients with hypertriglyceridemic acute pancreatitis. Conclusion: Poor blood lipid control, diabetes mellitus, and overweight or obesity are independent risk factors of recurrence in patients with hypertriglyceridemic acute pancreatitis. Strengthening the follow-up glucolipid management of patients can help reduce the influence of related risk factors on disease recurrence.