Objective To observe the clinical efficacy of Huatan Pingchuan prescription combined with doxofylline in the treatment of bronchial asthma, airway remodeling and the influence of corresponding indexes. Methods From February 2023 to April 2024, 116 patients with bronchial asthma admitted to the respiratory outpatient department and inpatient department of our hospital were selected as the study objects. 116 patients with bronchial asthma were randomly divided into observation group and control group with 58 cases in each group by random number table method. The control group was treated with doxofylline on the basis of conventional Western medicine treatment; Observation group was treated with Huatan Pingchuan prescription on the basis of control group. Clinical efficacy, TCM syndrome score, lung function [Forced expiratory volume for 1 second (FEV1), forced vital capacity (FVC), peak expiratory flow rate (PEF) ], asthma control [Asthma Control Test (ACT)], inflammatory factors [interleukin-6 (IL-6), interleukin-8 (IL-8), interferon-γ (IFN-γ)], and the incidence of adverse reactions were analyzed and compared between the two groups. Results The total effective rate of observation group was significantly higher than that of control group (P<0.05). After treatment, the total scores of cough, wheezing, phlegm in the throat, chest tightness, phlegm, wheezing in the lungs, shortness of breath, tongue quality and clinical symptoms in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the levels of lung function indexes FVC, FEV1 and PEF in observation group were higher than those in control group (P<0.05). After treatment, the ACT scores of both groups were significantly lower than before treatment, and the ACT scores of the observation group were significantly lower than those of the control group (P<0.05). After treatment, the levels of IL-6, IL-8 and IFN-γ in both groups were significantly lower than before treatment, and the levels of IL-6, IL-8 and IFN-γ in the observation group were significantly lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Huatan Pingchuan prescription combined with Western medicine can improve the clinical symptoms, improve the therapeutic effect, improve the lung function and asthma control of patients, and has high safety.