Objective: To perform multiloop edgewise arch wire (MEAW) and straight arch wire orthodontic technique for patients with Angle Class III malocclusion, and observe the clinical effect. Methods: From November 2021 to January 2024, 64 patients with Angle Class III malocclusion were selected from Zhixianglai Oral Clinic and Jingkai Zhide Oral Clinic of the hospital, and were divided into control group (32 cases, straight arch wire orthodontic technique combined with anchorage nail therapy) and study group (32 cases, MEAW on the basis of control group) according to the random coin tossing method. The cephalometric indicators such as SNA [angle composed of sella center (S point), nasal root point (N point) and upper alveolar seat point (A point)], SNB [angle composed of S, N point and lower alveolar seat point (B point)], ANB [angle composed of A, N point and B point], U1-SN (lower medial angle formed by the intersection of long axis of the maxillary central incisor and the skull base plane) and OB (horizontal distance between the upper and lower anterior incisors) before and after treatment and symmetry of tooth arrangement [UI-LI (inclination of upper and lower incisors), FH-MP (mandibular plane angle)] before and after treatment were compared between groups. The clinical indicators (normal coverage time of anterior teeth, total course of treatment) and occurrence of adverse reactions during treatment were observed and compared. Results: After 1 year of treatment, the cephalometric indicators (ANB, U1-SN, OB) in both groups were higher than those before treatment, and the indicators in study group were higher than those in control group (P<0.05), but there were no statistical differences in the cephalometric indicators (SNA, SNB) between groups (P>0.05). Compared with before treatment, the UI-LI and FH-MP in the two groups were higher after 1 year of treatment, and the indicators in study group were higher than those in control group (P<0.05). Compared with control group, the normal coverage time of anterior teeth and total course of treatment in study group were shorter (P<0.05). There was no statistical difference in the total incidence rate of adverse reactions (tooth loosening, root resorption, gingival irritation, oral ulcer) between study group and control group (P>0.05). Conclusion: MEAW and straight arch wire orthodontic technique can promote the normalization of dental structure, and shorten the normal coverage time of anterior teeth and total course of treatment in patients with Angle Class III malocclusion, and it has safety.