Objective: To explore the effect of pre-hospital emergency treatment combined with interventional vascular embolization on patients with multiple injuries. Methods: 64 patients with multiple injuries admitted to our hospital from March 2022 to October 2024 were selected as the study objects. Patients were divided into control group and observation group by random number table method, 32 cases in each group. The control group received pre-hospital emergency treatment; The observation group received pre-hospital emergency treatment combined with interventional vascular embolization. The levels of inflammatory factors [Interleukin-6 (IL-6) and C-reactive protein (CRP)], prognosis, length of stay and incidence of complications were analyzed and compared between the two groups. Results: After treatment, the levels of IL-6 and CRP in both groups were decreased compared with before treatment, and the levels of IL-6 and CRP in observation group were significantly decreased compared with control group (P<0.05). The incidence of adverse prognosis in the observation group was significantly lower than that in the control group (P<0.05). The incidence of complications in the observation group was significantly lower than that in the control group (P<0.05), and the length of hospitalization in the observation group was significantly shorter than that in the control group (P<0.05). Conclusion: Pre-hospital emergency treatment combined with interventional vascular embolization can reduce the level of inflammation in patients with multiple injuries, reduce the incidence of adverse prognosis and complications, and promote postoperative rehabilitation.