Objective: To explore the regulatory effects of atomized budesonide suspension on traumatic stress level and humoral immunity level of children after tonsil hypertrophic extraction. Methods: Ninety-eight cases of children with tonsil hyperplasia after operation from January 2023 to October 2024 in our department were selected as the study objects. 49 cases in the control group were given atomized inhalation of compound ipratropium bromide solution, and 49 cases in the observation group were atomized inhalation of budesonide suspension. The improvement effect of symptoms and signs, traumatic stress level, humoral immunity level and caregiver anxiety were compared between the two groups. Results: After 8 weeks of treatment, the incidence of snoring, sleep apnea and open mouth breathing decreased in both groups (P<0.05), and the incidence was lower in the observation group (P<0.05). Serum levels of procalcitonin, cortisol, prostaglandin E2 and prostaglandin F2α were decreased in both groups (P<0.05), and were lower in observation group (P<0.05). The levels of immunoglobulin M (IgM), IgG and IgA were increased in both groups (P<0.05), and higher in the observation group (P<0.05). The anxiety scores of the caregivers in the observation group were lower than those in the control group (P<0.05). Conclusion: Nebulized budesonide suspension can improve the symptoms and signs of children after tonsil hypertrophy extraction, alleviate traumatic stress, enhance humoral immunity, and improve the anxiety of caregivers.