Objective: To explore the application effect of cryoprecipitation combined with platelets and the other blood components in blood transfusion of patients with traumatic massive hemorrhage. Methods: A total of 60 patients with traumatic massive hemorrhage who needed blood transfusion in the hospital were enrolled between January 2024 and January 2025. According to random number table method, they were divided into group A (n=20, infusion of other blood components), group B (n=20, cryoprecipitation combined with infusion of other blood components) and group C (n=20, cryoprecipitation combined with platelet and the other blood components). The four blood coagulation indexes and platelet count (PLT) before and at 24h after infusion, length of hospital stay, hemostasis time and infusion volume of blood products were compared among the three groups. Results: Compared with groups A and B, FIB and PLT were higher, TT, APTT and PT were shorter in group C at 24h after infusion (P<0.05). Compared with groups A and B, length of hospital stay and hemostasis time were shorter in group C (P<0.05). There was no significant difference in infusion volume of red blood cells among the three groups (P>0.05), but infusion volume of cryoprecipitate in group C was less than that in group B (P<0.05). Conclusion: Cryoprecipitation combined with platelet and the other blood components infusion can effectively improve coagulation function, shorten hemostasis time and length of hospital stay in patients with traumatic massive hemorrhage.