Objective: To investigate the value of interleukin-6 (IL-6), serum amyloid A (SAA), and? C-reactive protein (CRP) in evaluating the severity of Mycoplasma pneumoniae pneumonia (MPP) in children. Methods: Sixty children admitted to the hospital from January 2022 to August 2024 due to MPP were selected and divided into mild group (n=37) and severe group (n=23) according to the severity. The levels of IL-6, SAA and CRP were compared between the two groups. Logistic regression analysis was used to identify risk factors for severe MPP. The predictive value of IL-6, SAA, and CRP levels for severe MPP was analyzed using receiver operating characteristic (ROC) curves. Results: The levels of IL-6, SAA, and CRP in severe group were higher than those in mild group (P<0.05). Logistic regression analysis found that IL-6, SAA, and CRP were independent risk factors for severe MPP (P<0.05). ROC analysis showed that the areas under the curve of IL-6, SAA, and CRP for predicting severe MPP were 0.784, 0.896, and 0.851. Conclusion: Serum IL-6, SAA, and CRP levels in children with severe MPP are higher than those in children with mild MPP. IL-6, SAA, and CRP are independent risk factors for severe MPP and participate in the progression of MPP in children.