Objective: To explore the effect of laparoscopic myomectomy for the treatment of uterine fibroids and its impact on clinical indicators. Method: A retrospective analysis was conducted on 94 patients with uterine fibroids who underwent myomectomy at Department of Gynecology of Xinyang People"s Hospital from January 2022 to May 2024. They were divided into an open surgery group (n=43) and a laparoscopic group (n=51) according to different surgical methods. Preoperative and postoperative 3d traumatic indexes [myoglobin (MYO), ishama-modified albumin (IMA)], ovarian function [follicle stimulating hormone (FSH), luteinizing hormone (LH)], postoperative complications and recurrence of the two groups were statistically analyzed and compared. Results Compared with the open surgery group, the laparoscopic group had less intraoperative bleeding, longer surgery time, and shorter hospital stay (P<0.05). Before surgery, there was no significant difference in trauma indicators and ovarian function between the two groups (P>0.05). On postoperative day 3, both groups showed an increase in MYO and IMA, with the laparoscopic group being lower than the open group (P<0.05). One month after surgery, FSH and LH levels increased in both groups, and the laparoscopic group was lower than the open group (P<0.05). There was no significant difference in the incidence of complications and recurrence rate between the two groups (P>0.05). Conclusion: Laparoscopic myomectomy for the treatment of uterine fibroids is minimally invasive, beneficial for postoperative recovery, reduces tissue trauma, and has minimal impact on ovarian function.