Objective To investigate the effects of sevoflurane combined with propofol anesthesia on the quality of recovery and hemodynamic indexes in patients undergoing laparoscopic cholecystectomy (LC). Methods 90 patients who underwent elective LC in our hospital from October 2022 to September 2024 were selected as the study objects. 90 patients were divided into control group and compound group by random number table method, with 45 cases in each group. The control group was anesthetized with propofol; The compound group was anesthetized by propofol combined with sevoflurane. The dosage of propofol, resuscitation quality, Mean arterial pressure (MAP, heart rate (HR)], cognitive function [Mini-Mental State Examination (MMSE)] of the two groups were analyzed and compared. Results Compared with control group, the dosage of propofol in compound group was significantly decreased, and the time of eye opening, recovery time of spontaneous respiration and extubation time were significantly shortened (P < 0.05). There were no significant differences in HR and MAP between the two groups at different time points of entry, immediate intubation, skin incision, abdominal closure and extubation (P > 0.05). Before operation, there was no significant difference in MMSE scores between the two groups (P > 0.05). At 6h after operation, MMSE scores of both groups were significantly lower than those before operation, and MMSE scores of compound group were significantly higher than those of control group (P < 0.05). Conclusion Sevoflurane combined with propofol can reduce the amount of propofol, improve the quality of recovery and reduce the influence on cognitive function during LC.