Objective: To evaluate the value of combined detection of D-dimer and Fibrin Degradation Products (FDP) in the early diagnosis of Pulmonary Embolism (PE). Methods: 121 patients with suspected pulmonary embolism admitted to our hospital from January 2022 to December 2023 were selected as the study objects. All patients were examined by CT pulmonary angiography (CTPA). Using CTPA results as the gold standard, patients were divided into pulmonary embolism group and non-pulmonary embolism group. Baseline data were collected and compared between the two groups. The D-dimer and FDP levels of the two groups were detected and compared. The influencing factors of pulmonary embolism were analyzed by Logistic regression. The efficacy of D-dimer and FDP in diagnosing pulmonary embolism was evaluated by Receiver Operating Characteristic (ROC). Results: Among 121 suspected patients with pulmonary embolism, 59 cases were confirmed as pulmonary embolism and included in the pulmonary embolism group. Sixty-two patients with non-pulmonary embolism were included in the non-pulmonary embolism group. The levels of age, D-dimer and FDP in pulmonary embolism group were significantly higher than those in non-pulmonary embolism group (P<0.05). Logistic regression analysis showed that age, D-dimer and FDP levels were risk factors for pulmonary embolism (P<0.05). The sensitivity and specificity of D-dimer alone diagnosis were 89.8% and 85.5%, the sensitivity and specificity of FDP alone diagnosis were 86.4% and 90.3%, and the sensitivity and specificity of combined diagnosis were 94.9% and 80.4%. Conclusion: D-dimer and FDP are risk factors for pulmonary embolism, and their combination has high sensitivity and relatively good specificity in early diagnosis of pulmonary embolism.