Objective: To study the effect of Shenqi Buxin Decoction combined with Shakubatryl valsartan on patients with chronic heart failure. Methods: The patients were divided into control group and study group by random number table, with 51 cases in each group. The control group was treated with sakubatrol and valsartan. The study group was treated with Shenqi Buxin Decoction combined with Sakubactril valsartan. The clinical efficacy, TCM syndrome scores, cardiac function indexes [early/late diastolic maximum blood flow velocity (E/A), left ventricular ejection fraction (LVEF), heart index (CI), stroke volume (SV)], serum factors [Malondialdehyde (MDA), superoxide dismutase (SOD), silence-regulating protein 4 (SIRT4), and signal transducers and transcriptional activators 3 (STAT3)] and the incidence of adverse reactions of the two groups were analyzed and compared. Results: The total effective rate of the study group was significantly higher than that of the control group (P < 0.05). After treatment, TCM syndrome score of both groups was significantly lower than that before treatment, and the TCM syndrome score of the study group was significantly lower than that of the control group (P < 0.05). After treatment, the cardiac function indexes of E/A, LVEF, CI and SV in both groups were significantly higher than those before treatment, and the cardiac function indexes in the study group were significantly higher than those in the control group (P < 0.05). After treatment, MDA, SIRT4 and STAT3 levels in both groups were significantly decreased before treatment, and SOD levels were significantly increased compared with those before treatment. The changes of serum factors in the study group were significantly greater than those in the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion: Shenqi Buxin Decoction combined with Sakubactril valsartan can promote the improvement of clinical symptoms and cardiac function in CHF patients, reduce the degree of oxidative stress, improve efficacy, and have good safety.