Objective To investigate the risk factors of poor prognosis in patients with acute ischemic stroke (AIS) after interventional surgery. Methods 241 patients with AIS admitted to our hospital from February 2020 to February 2024 were selected as the study objects. All patients received interventional therapy. The improved Rankin Scale (mRS) was used to evaluate the prognosis of the patients 3 months after treatment. Baseline data of patients with different outcomes were collected and compared. Logistic regression model was used to analyze the risk factors of poor prognosis in AIS patients after interventional surgery. The prediction model is constructed and its fitting effect is analyzed. Results Among 241 AIS patients, 96 (39.83%) had poor prognosis after interventional operation. There were significant differences between the poor prognosis group and the good prognosis group in diabetes, hypertension, time from onset to interventional treatment, NIHSS score before interventional treatment, large cerebral infarction, white blood cell count and CRP at admission (P < 0.05). Hypertension, time from onset to interventional therapy, NIHSS score before interventional therapy, large cerebral infarction, white blood cell count at admission and CRP were all factors influencing the poor prognosis of AIS patients after interventional therapy (P < 0.05). Conclusion There is a high incidence of poor prognosis in AIS patients after interventional intervention, and the influencing factors include hypertension, time from onset to interventional treatment, NIHSS score before interventional treatment, large cerebral infarction, white blood cell count and CRP at admission.