布地奈德与特布他林联合甲泼尼龙对大叶性肺炎患儿临床症状及D-二聚体水平、肺功能的影响
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平舆县人民医院

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Effects of budesonide and terbutaline combined with methylprednisolone on clinical symptoms, D-dimer level and lung function in children with lobar pneumonia
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    摘要:

    目的 分析布地奈德与特布他林联合甲泼尼龙对大叶性肺炎(LP)患儿临床症状及D-二聚体(D-D)水平、肺功能的影响。方法 回顾性收集2022年10月~2023年8月期间在本院就诊的94例LP患儿的临床资料。根据治疗方案不同将患儿分为对照组(给予布地奈德与特布他林治疗,47例)和观察组(给予布地奈德与特布他林联合甲泼尼龙治疗,47例)。收集比较两组的临床疗效、临床症状消失时间、肺功能[达峰时间比(TPTEF/TE)、达峰容积比(VPTEF/VE)、潮气量(Vt/kg)]、血清相关因子[白介素-6(IL-6)、D-D]水平以及不良反应。结果 观察组的治疗总有效率显著高于对照组(P<0.05)。治疗后,观察组的啰音消失时间、肺部阴影吸收时间、退热时间、咳喘消失时间各项临床症状消失时间均比对照组显著缩短(P<0.05)。治疗后,两组的VPTEF/VE、TPTEF/TE、Vt/kg水平均比治疗前显著升高,且观察组的VPTEF/VE、TPTEF/TE、Vt/kg水平均比对照组显著升高(P<0.05)。治疗后,两组的D-D、IL-6水平均比治疗前显著降低,且观察组的D-D、IL-6水平均显著低于对照组(P<0.05)。两组的不良反应发生率无显著差异(P>0.05)。结论 布地奈德与特布他林联合甲泼尼龙治疗LP患儿,能提高疗效,缓解临床症状,调节肺功能,减轻体内炎症反应,且安全性较高。

    Abstract:

    Objective To analyze the effects of budesonide and terbutaline combined with methylprednisolone on clinical symptoms, D-dimer (D-D) level and lung function in children with lobar pneumonia (LP). Methods The clinical data of 94 children with LP who were treated in our hospital from October 2022 to August 2023 were retrospectively collected. Children were divided into control group (budesonide and terbutaline treatment, 47 cases) and observation group (budesonide and terbutaline combined with methylprednisolone treatment, 47 cases). Clinical efficacy, duration of clinical symptom resolution, lung function [TPTEF/TE], VPTEF/VE, tidal volume (Vt/kg)], serum related factors [interleukin-6 (IL-6), D-D] levels and adverse reactions were collected and compared between the two groups. Results The total effective rate of observation group was significantly higher than that of control group (P < 0.05). After treatment, the disappearance time of rales, lung shadow absorption time, fever reduction time, cough and wheezing time of clinical symptoms in the observation group were significantly shorter than those in the control group (P < 0.05). After treatment, the levels of VPTEF/VE, TPTEF/TE and Vt/kg in both groups were significantly higher than before treatment, and the levels of VPTEF/VE, TPTEF/TE and Vt/kg in the observation group were significantly higher than those in the control group (P < 0.05). After treatment, the D-D and IL-6 levels in both groups were significantly lower than before treatment, and the D-D and IL-6 levels in the observation group were significantly lower than those in the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Budesonide and terbutaline combined with methylprednisolone in the treatment of LP children can improve the efficacy, relieve clinical symptoms, regulate lung function, reduce inflammation in vivo, and have high safety.

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于明丽.布地奈德与特布他林联合甲泼尼龙对大叶性肺炎患儿临床症状及D-二聚体水平、肺功能的影响[J].四川生理科学杂志,2025,47(6):

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  • 收稿日期:2025-02-07
  • 最后修改日期:2025-03-14
  • 录用日期:2025-04-02
  • 在线发布日期: 2025-06-22
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