Objective To investigate the effect of continuous airway humidification combined with intermittent atomization inhalation in patients with tracheotomy of cerebral hemorrhage. Methods 94 patients with cerebral hemorrhage admitted to our hospital from October 2022 to October 2024 were selected as the study objects. The patients were divided into control group and observation group by random number table, with 47 cases in each group. The control group received continuous airway humidification. The observation group was treated with continuous airway humidification combined with intermittent atomization inhalation. Airway humidification effect, vital signs [diastolic blood pressure (DBP), heart rate (HR), respiratory (R) and systolic blood pressure (SBP)], blood gas analysis indexes [arterial partial oxygen pressure(PaO2), Arterial carbon dioxide pressure (PaCO2), blood oxygen saturation (SaO2) and tidal volume (VT)] and complications of the two groups were analyzed and compared. Results The effect of airway humidification in the observation group was significantly higher than that in the control group (P < 0.05). After intervention, SBP, HR, DBP and R in both groups were significantly higher than before intervention, but SBP, HR, DBP and R in the observation group were significantly lower than those in the control group (P < 0.05). After intervention, PaCO2 in both groups was significantly higher than before intervention, while PaO2, VT and SaO2 were significantly lower than before intervention. After intervention, PaCO2 in the observation group was significantly lower than that in the control group, and PaO2, VT and SaO2 were significantly higher than that in the control group (P < 0.05). The complication rate of the observation group was significantly lower than that of the control group (P < 0.05). Conclusion Continuous airway humidification combined with intermittent aerosol inhalation can improve airway humidification effect, stabilize vital signs, improve blood gas analysis index and reduce complications in patients with cerebral hemorrhage tracheotomy.