Objective: To explore the clinical effect of uterine balloon compression combined with carprost triol in the treatment of postpartum hemorrhage caused by uterine fatigue. Methods: The clinical data of 89 patients with postpartum hemorrhage after delivery in the obstetric department of our hospital from June 2021 to June 2023 were retrospectively collected. According to the different treatment methods, the patients were divided into control group (receiving caprost triamine treatment, 44 cases) and observation group (receiving uterine balloon compression combined with caprost triamine treatment, 45 cases). The contraction intensity, blood loss, hemostatic time and the sum of three diameters of uterus were analyzed and compared between the two groups. Results: At 1h and 2h postpartum, the intensity of uterine contractions in both groups increased to different degrees compared with 30min postpartum, and the intensity of uterine contractions at 1h and 2h postpartum in the observation group was significantly higher than that in the control group (P < 0.05). The amount of postpartum blood loss in the observation group was significantly reduced than that in the control group at 2h and 24h, and the time for hemostasis was significantly shortened (P < 0.05). On postpartum day 3 and 7, the sum of three diameters of uterus in both groups decreased compared with that on postpartum day 1, and the sum of three diameters of uterus in the observation group was significantly lower than that in the control group on postpartum day 3 and 7 (P < 0.05). Conclusion: The combination of uterine balloon compression and carprost trochantriol in the treatment of postpartum hemorrhage with uterine fatigue can enhance the postpartum uterine strength, reduce the amount of bleeding, achieve rapid hemostasis, and promote uterine rehabilitation.