Objective: To investigate the effect of ursodeoxycholic acid combined with polyene phosphatidylcholine on serum bile acid profile and abnormal liver function in patients with intrahepatic cholestasis during pregnancy. Methods: Sixty patients with intrahepatic cholestasis of pregnancy admitted to the Affiliated Hospital of Shangrao University of Health from January 2021 to April 2023 were selected as the study objects and randomly divided into two groups: control group (30 cases) receiving 200 mg （Three times d minus one) ursodeoxycholic acid, and treatment group (30 cases) receiving ursodeoxycholic acid and intravenous injection of 10 ml polyene phosphatidyl choline. Itch score, liver function index (including total bilirubin, alanine aminotransferase, aspartate aminotransferase and direct bilirubin), oxidative stress index (including glutathione peroxidase, superoxide dismutase, and peroxide malondialdehyde) and bile acid spectrum related index (including bile acid spectrum taurocholic acid, goosenodeoxycholic acid, bile) were compared between the two groups before and after 10 days of treatment Acid, glycinocholic acid and lithocholic acid levels). Results:After 10 days of treatment, the itching score evaluated by the itching score system developed by Ribalta after treatment was lower than that before treatment, and the itching score in the treatment group was significantly lower than that in the control group (P < 0.05). After 10 days of treatment, the levels of total bilirubin, alanine aminotransferase, aspartate aminotransferase and direct bilirubin in the treatment group were significantly lower than those in the control group (P < 0.05). After 10 days of treatment, the levels of glutathione peroxidase and superoxide dismutase measured by enzyme-linked immunosorbent assay were significantly higher in the treatment group than in the control group (P < 0.05). After 10 days of treatment, the levels of malondialdehyde peroxide and serum bile acid profiles of taurocholic acid, cholic acid, glycyrcholic acid and stone cholic acid in the treatment group were significantly lower than those in the control group (P < 0.05).Conclusion: Ursodeoxycholic acid combined with polyene phosphatidylcholine has a significant effect on intrahepatic cholestasis of pregnancy, can significantly improve liver function and inhibit bile acid secretion.