Objective: To analyze the clinical features of novel Bunyavirus infection. Methods The clinical data of 81 patients with novel Bunyavirus infection admitted to our hospital from March 2020 to October 2022 were retrospectively analyzed. The clinical features and prognosis of novel Bunyavirus infection were analyzed and compared, and the laboratory indicators and nucleic acid quantification of patients with different prognosis were compared. Results: Among the 81 patients infected with new Bunia virus, 37.04% were male and 62.96% were female. 98.77% of the patients lived in rural areas of hills or mountains. Fever and fatigue were the main clinical manifestations. 70-79 years old were the most common age group with the highest incidence in summer. Of the 81 patients, 63 were cured and 18 died. The platelet count, fibrinogen, serum calcium and glomerular filtration rate of the deceased patients were lower than those of the cured patients. Alanine aminotransferase, troponin Ⅰ, creatine kinase, creatine kinase isoenzyme, prothrombin time, activated partial thromboplastin time, potassium ion, tumor necrosis factor, D-dimer, interleukin-6, interleukin-8, interleukin-10, procalcitonin, γ-glutamyl transaminase, glutamic oxalacetic transaminase, lactate dehydrogenase, serum creatinine, nucleic acid quantities were higher than those of cured patients (P < 0.05). Conclusion New Bunyavirus infection is most common in rural areas living in hilly or mountainous areas. The incidence of new Bunyavirus infection is higher in females, and it is concentrated in 70-79 years of age and summer. The clinical symptoms are mainly fever and fatigue, and laboratory indicators such as liver, kidney, inflammatory factors, coagulation and viral load are related to the prognosis of patients.